Pharmacy - Graduate Pharmacy Aptitude Test (GPAT)

Drug Delivery, Mechanism of Action & Natural Products question bank (Pharmaceutics, Pharmacology & Pharmacognosy)

Practice 143 free Pharmacy - Graduate Pharmacy Aptitude Test (GPAT) Pharmaceutics, Pharmacology & Pharmacognosy - Drug Delivery, Mechanism of Action & Natural Products questions with answers and step-by-step solutions.

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Q1.

GPAT Pharmacology: What is the primary molecular mechanism of action of ACE Inhibitors (such as Enalapril and Captopril) in 'Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability'?

(A)

Inhibition of Angiotensin Converting Enzyme, preventing conversion of Angiotensin I to vasoconstrictor Angiotensin II (Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability)

(B)

Blockade of beta-1 adrenergic receptors on cardiac myocardium

(C)

Direct opening of vascular potassium channels

(D)

Inhibition of renal sodium-glucose cotransporter 2 (SGLT2)

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Q2.

Pharmaceutics (Dissolution Kinetics): In 'Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability', which fundamental physical equation expresses the rate of solid drug dissolution: $\\frac{dC}{dt} = \\frac{DA}{h}(C_s - C)$?

(A)

Noyes-Whitney Equation (Pharmaceutics: Solid Dosages, Tablet Compression, Coating, Dissolution and Bioavailability)

(B)

Stokes' Equation

(C)

Michaelis-Menten Equation

(D)

Henderson-Hasselbalch Equation

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