NEET PG & INI-CET - Para-Clinical Sciences (Pathology, Pharmacology & Microbiology)

Systemic Pathology question bank (Pathology & Genetics)

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Q1.

[Pathology & Genetics] Case Assessment #2: A 62-year-old male with chronic myeloid leukemia (CML) carries the t(9;22)(q34;q11) translocation. What is the molecular target?

(A)

BCR-ABL fusion oncoprotein with constitutive tyrosine kinase activity

(B)

JAK2 V617F point mutation conferring cytokine hypersensitivity

(C)

FLT3 internal tandem duplication accelerating blast proliferation

(D)

PML-RARA fusion inhibiting granulocyte differentiation

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Q2.

[Medical Pharmacology] Case Assessment #3: A 55-year-old hypertensive patient with type 2 diabetes and microalbuminuria requires therapy. What is the first-line agent?

(A)

ACE inhibitor or Angiotensin Receptor Blocker (ARB) due to efferent arteriolar vasodilation

(B)

Thiazide diuretic due to inhibition of Na-Cl cotransporter in proximal tubule

(C)

Dihydropyridine CCB due to selective constriction of afferent arteriole

(D)

Beta-blocker due to negative inotropic and chronotropic suppression

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