NEET PG & INI-CET - Para-Clinical Sciences (Pathology, Pharmacology & Microbiology)

Neoplasia & Hematology question bank (Pathology & Genetics)

Practice 3,378 free NEET PG & INI-CET - Para-Clinical Sciences (Pathology, Pharmacology & Microbiology) Pathology & Genetics - Neoplasia & Hematology questions with answers and step-by-step solutions.

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Q1.
[Pathology & Genetics] Case Assessment #2: A 62-year-old male with chronic myeloid leukemia (CML) carries the t(9;22)(q34;q11) translocation. What is the molecular target?

(A)
FLT3 internal tandem duplication accelerating blast proliferation
(B)
PML-RARA fusion inhibiting granulocyte differentiation
(C)
BCR-ABL fusion oncoprotein with constitutive tyrosine kinase activity
(D)
JAK2 V617F point mutation conferring cytokine hypersensitivity
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Q2.
[Pathology & Genetics] Case Assessment #3: A 62-year-old male with chronic myeloid leukemia (CML) carries the t(9;22)(q34;q11) translocation. What is the molecular target?

(A)
PML-RARA fusion inhibiting granulocyte differentiation
(B)
FLT3 internal tandem duplication accelerating blast proliferation
(C)
BCR-ABL fusion oncoprotein with constitutive tyrosine kinase activity
(D)
JAK2 V617F point mutation conferring cytokine hypersensitivity
Show answer & solution
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